Membrane-associated GTPases in bacteria

Mol Microbiol. 1992 May;6(10):1253-7. doi: 10.1111/j.1365-2958.1992.tb00845.x.


Members of the GTPase superfamily are extremely important in regulating membrane signalling pathways in all cells. This review focuses on membrane-associated GTPases that have been described in prokaryotes. In bacteria, LepA and NodQ are very similar to protein synthesis elongation factors but apparently have membrane-related functions. The amino acid sequences of FtsY and Ffh are clearly related to eukaryotic factors involved in protein secretion. Obg and Era are not closely related to any GTPase subgroup according to amino acid sequence comparisons, but they are essential for viability. In spite of similarities to well-studied eukaryotic proteins the signalling pathways of these cellular regulators, with the exception of NodQ, have not yet been elucidated.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Amino Acid Sequence
  • Bacterial Proteins* / genetics
  • Bacterial Proteins* / metabolism
  • Consensus Sequence
  • GTP Phosphohydrolase-Linked Elongation Factors* / genetics
  • GTP Phosphohydrolase-Linked Elongation Factors* / metabolism
  • Gene Expression Regulation, Bacterial
  • Genes, Bacterial
  • Guanosine Triphosphate / metabolism*
  • Molecular Sequence Data
  • Multigene Family
  • Peptide Elongation Factors / genetics
  • Peptide Elongation Factors / metabolism
  • Signal Transduction


  • Bacterial Proteins
  • Peptide Elongation Factors
  • Guanosine Triphosphate
  • GTP Phosphohydrolase-Linked Elongation Factors