Management of persons exposed to multidrug-resistant tuberculosis

MMWR Recomm Rep. 1992 Jun 19;41(RR-11):61-71.


Recent outbreaks of multidrug-resistant tuberculosis (MDR-TB) have posed challenges for the management of exposed persons. This report offers suggestions for evaluating and managing persons (i.e., contacts) who have been exposed to patients with infectious MDR-TB (TB due to strains of Mycobacterium tuberculosis resistant to both isoniazid [INH] and rifampin [RIF]), provides background information on alternative preventive therapy regimens with drugs other than INH or RIF, and presents considerations relevant to making a decision to offer one of these alternative regimens.

MeSH terms

  • Antitubercular Agents / therapeutic use*
  • Clinical Protocols
  • Disease Outbreaks / prevention & control
  • Drug Resistance, Microbial
  • Drug Therapy, Combination
  • Humans
  • Mycobacterium tuberculosis / drug effects*
  • Tuberculosis / drug therapy
  • Tuberculosis / prevention & control*
  • Tuberculosis / transmission


  • Antitubercular Agents