The gene lin-3 encodes an inductive signal for vulval development in C. elegans

Nature. 1992 Aug 6;358(6386):470-6. doi: 10.1038/358470a0.


The lin-3 gene is necessary for induction of the Caenorhabditis elegans vulva by the anchor cell. It encodes a molecule similar to epidermal growth factor and to transforming growth factor-alpha and acts through the epidermal growth factor receptor homologue let-23. Expression of lin-3 in the anchor cell stimulates vulval induction; lin-3 may encode the vulval inducing signal.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Animals, Genetically Modified
  • Base Sequence
  • Caenorhabditis / embryology*
  • Caenorhabditis / genetics*
  • Caenorhabditis elegans Proteins*
  • Cloning, Molecular
  • Disorders of Sex Development
  • Embryonic Induction / genetics*
  • Epidermal Growth Factor / genetics
  • Female
  • Helminth Proteins / genetics
  • Molecular Sequence Data
  • Recombinant Fusion Proteins
  • Stem Cells / physiology
  • Vulva / embryology


  • Caenorhabditis elegans Proteins
  • Helminth Proteins
  • Recombinant Fusion Proteins
  • Lin-3 protein, C elegans
  • Epidermal Growth Factor