Human infection by genetically diverse SIVSM-related HIV-2 in west Africa

Nature. 1992 Aug 6;358(6386):495-9. doi: 10.1038/358495a0.


Our understanding of the biology and origins of human immunodeficiency virus type 2 (HIV-2) derives from studies of cultured isolates from urban populations experiencing epidemic infection and disease. To test the hypothesis that such isolates might represent only a subset of a larger, genetically more diverse group of viruses, we used nested polymerase chain reactions to characterize HIV-2 sequences in uncultured mononuclear blood cells of two healthy Liberian agricultural workers, from whom virus isolation was repeatedly unsuccessful, and from a culture-positive symptomatic urban dweller. Analysis of pol, env and long terminal repeat regions revealed the presence of three highly divergent HIV-2 strains, one of which (from one of the healthy subjects) was significantly more closely related to simian immunodeficiency viruses infecting sooty mangabeys and rhesus macaques (SIVSM/SIVMAC) than to any virus of human derivation. This subject also harboured multiply defective viral genotypes that resulted from hypermutation of G to A bases. Our results indicate that HIV-2, SIVSM and SIVMAC comprise a single, highly diverse group of lentiviruses which cannot be separated into distinct phylogenetic lineages according to species of origin.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Amino Acid Sequence
  • Base Sequence
  • Genes, env
  • Genes, pol
  • Genetic Variation
  • HIV Infections / microbiology*
  • HIV Long Terminal Repeat
  • HIV-2 / genetics*
  • Humans
  • Liberia
  • Male
  • Middle Aged
  • Molecular Sequence Data
  • Phylogeny
  • Simian Immunodeficiency Virus / genetics*

Associated data

  • GENBANK/M87069
  • GENBANK/M87070
  • GENBANK/M87071
  • GENBANK/M87072
  • GENBANK/M87073
  • GENBANK/M87074
  • GENBANK/M87075
  • GENBANK/M87076
  • GENBANK/M87077
  • GENBANK/M87078
  • GENBANK/M87079
  • GENBANK/M87080
  • GENBANK/M87081
  • GENBANK/M87082
  • GENBANK/M87083
  • GENBANK/M87084
  • GENBANK/M87085
  • GENBANK/M87086
  • GENBANK/M87087
  • GENBANK/M87088
  • GENBANK/M87089
  • GENBANK/M87090
  • GENBANK/M87091
  • GENBANK/M87092
  • GENBANK/M87093
  • GENBANK/M87094
  • GENBANK/M87095
  • GENBANK/M87096
  • GENBANK/M87097
  • GENBANK/M87098