The SHREW1 gene, frequently deleted in oligodendrogliomas, functions to inhibit cell adhesion and migration

Cancer Biol Ther. 2006 Mar;5(3):300-4. doi: 10.4161/cbt.5.3.2391. Epub 2006 Mar 9.


Allelic loss of the short arm of chromosome 1 has been observed frequently in oligodendroglioma (60-80%). We evaluated 177 oligodendroglial tumor samples and defined a consensus region of deletion of approximately 630 kb. This region contains a single gene, SHREW1, which encodes a novel transmembrane protein in adherens junctions. Whereas a mutation was not detected in the coding region of the SHREW1 gene in oligodendrogliomas, restoration of SHREW1 expression resulted in suppression of cell adhesion and migration. Thus, SHREW1 inactivation may play a role in the development of oligodendroglial tumors.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Adhesion Molecules
  • Cell Adhesion*
  • Cell Movement*
  • Gene Deletion
  • Genes, Tumor Suppressor*
  • Humans
  • Membrane Proteins / genetics*
  • Membrane Proteins / physiology
  • Microsatellite Repeats
  • Mutation
  • Oligodendroglioma / genetics*
  • Oligodendroglioma / pathology*
  • Polymerase Chain Reaction
  • Transfection


  • AJAP1 protein, human
  • Cell Adhesion Molecules
  • Membrane Proteins