Second and third malignant solid tumor in a girl with ovarian Sertoli-Leydig tumor

Pediatr Blood Cancer. 2006 May 1;46(5):654-6. doi: 10.1002/pbc.20486.

Abstract

We report a Sertoli-Leydig cell (SLC) tumor of the right ovary in a 10-year-old girl, which was dealt with surgical removal. Three months after resection, she presented with a new episode of acute abdomen because of an abdominal mass, which histologically was compatible with an undifferentiated embryonal rhabdomyosarcoma. Chemotherapy, according to SIOP-??? 89 protocol, was administered additionally to radiotherapy (3,960 cGy). Three years after completing treatment, the patient developed a painful swelling at her left upper arm. The diagnosis was Ewing sarcoma of the humerus, which was confirmed by identification of the typical 11; 22 translocation on cytogenetic and molecular analysis of the tumor tissue. The patient died 14 months from Ewing diagnosis due to progressive disease.

Publication types

  • Case Reports

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Child
  • Chromosomes, Human, Pair 12 / genetics
  • Chromosomes, Human, Pair 22 / genetics
  • Fatal Outcome
  • Female
  • Humans
  • Neoplasms, Multiple Primary / pathology*
  • Ovarian Neoplasms / pathology*
  • Sertoli-Leydig Cell Tumor / pathology*
  • Translocation, Genetic