Relevance of callosal and periventricular MRI lesions to oligoclonal bands in multiple sclerosis

Acta Neurol Scand. 2006 Feb;113(2):125-31. doi: 10.1111/j.1600-0404.2005.00552.x.


Objectives: To evaluate the association between callosal or periventricular lesions, and the presence of oligoclonal IgG bands (OB) or the IgG index in Japanese patients with multiple sclerosis (MS).

Materials and methods: Brain magnetic resonance imaging (MRI) was studied in 34 Japanese clinically definite MS cases. Sagittal 2-mm fast fluid-attenuated inversion-recovery (FLAIR) imaging was added to the routine MRI studies.

Results: Among the 34 patients, 20 (59%) were OB positive. Among the 20 patients with OB-positive MS, 17 (85%) had callosal lesions, although only two (14%) of 14 OB-negative MS patients had callosal lesions. The periventricular lesion area was significantly larger in the OB-positive patients compared with the OB-negative patients.

Conclusions: The present study clearly demonstrated a strong association between the periventricular lesions and OB in Japanese MS. Certain OB-related immune mechanisms may contribute to the development of callosal and periventricular lesions in MS. OB may be an important factor to understand the pathomechanisms of MS lesions.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Asians
  • Atrophy / etiology
  • Atrophy / metabolism
  • Atrophy / pathology
  • Cerebral Ventricles / pathology*
  • Corpus Callosum / pathology*
  • Female
  • Humans
  • Immunoglobulin G / metabolism*
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Multiple Sclerosis, Relapsing-Remitting / ethnology
  • Multiple Sclerosis, Relapsing-Remitting / metabolism*
  • Multiple Sclerosis, Relapsing-Remitting / pathology*
  • Oligoclonal Bands / metabolism*


  • Immunoglobulin G
  • Oligoclonal Bands