Age dependency and mutual relations in T and B lymphocyte abnormalities in common variable immunodeficiency patients

Clin Exp Immunol. 2006 Feb;143(2):373-9. doi: 10.1111/j.1365-2249.2006.02999.x.


Common variable immunodeficiency (CVID) is primary hypogammaglobulinaemia with an unknown aetiopathogenesis. Although various abnormalities of T and B cells have been described, their pathogenetic roles are unclear. We determined T and B lymphocyte subsets known to be abnormal in CVID in order to disclose possible relations between numerical abnormalities in those cells. Markers associated with B cell development (CD21, CD27, IgM, IgD) were determined on B lymphocytes (CD19+); T lymphocyte development (CD45RA, CD45RO, CD62L) and activation markers (CD25, CD27, CD28, CD29, CD38, CD57, HLA-DR) were determined on CD4+ and CD8+ T lymphocytes in 42 CVID patients and in 33 healthy controls. Abnormalities in CD4+ T lymphocyte activation markers (increase in CD29, HLA-DR, CD45RO, decrease in CD27, CD62L, CD45RA) were observed particularly in patients with a decreased number of memory (CD27+) and mature (CD21+) B cells (group Ia according to the Freiburg group's classification), while abnormalities observed in CD8+ cells (increase in CD27 and CD28 and decrease in HLA-DR, CD57 and CD38) did not depend upon grouping patients together according to B lymphocyte developmental subpopulations. We observed correlations between immature B cells (IgM+ CD21-) and expression of CD27, CD62L, CD45RA, CD45RO and HLA-DR on CD4+ T cells in CVID patients but not in the control group. The expression of CD27 and CD45RA on CD4+ T lymphocytes, such as the percentage of IgD+ CD27- and IgD+ CD27+ cells in B lymphocytes, showed age dependency to be more significant than in the control group. Our study demonstrates that T and B lymphocyte abnormalities in CVID are partially related to each other. Some of those abnormalities are not definite, but may evolve with age of the patient.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aging / immunology*
  • Antigens, CD / immunology
  • Antigens, Differentiation, B-Lymphocyte / immunology
  • Antigens, Differentiation, T-Lymphocyte / immunology
  • B-Lymphocyte Subsets / immunology
  • B-Lymphocytes / immunology*
  • Biomarkers / analysis
  • CD4-Positive T-Lymphocytes / immunology
  • CD8-Positive T-Lymphocytes / immunology
  • Common Variable Immunodeficiency / classification
  • Common Variable Immunodeficiency / immunology*
  • Female
  • Flow Cytometry / methods
  • Humans
  • Immunoglobulin D / immunology
  • Immunoglobulin M / immunology
  • Lymphocyte Activation / immunology
  • Male
  • Middle Aged
  • T-Lymphocytes / immunology*


  • Antigens, CD
  • Antigens, Differentiation, B-Lymphocyte
  • Antigens, Differentiation, T-Lymphocyte
  • Biomarkers
  • Immunoglobulin D
  • Immunoglobulin M