CD30+ lymphoproliferative disorders: histopathology, differential diagnosis, new variants, and simulators

J Cutan Pathol. 2006 Feb:33 Suppl 1:58-70. doi: 10.1111/j.0303-6987.2006.00548.x.


CD30+ lymphoproliferative disorders of the skin (CD30+ LPD) represent a well-defined spectrum of primary cutaneous T-cell lymphomas which have been recognized as distinct entities in recent lymphoma classifications. Lymphomatoid papulosis and anaplastic large-cell lymphoma share the expression of CD30 antigen as a common phenotypic hallmark but differ in regard to their clinical and histologic features as well as their biologic behavior. This article summarizes the histologic features of CD30+ LPD and presents recently identified new clinicopathologic variants of CD30+ LPD. There is an increasing number of reactive inflammatory disorders and neoplastic diseases which are composed of or contain a significant number of CD30+ cells and mimic LyP or anaplastic large cell lymphoma clinically or histologically. Differential diagnostic considerations focus on other lymphoproliferative processes with CD30+ tumor cells as well as non-lymphoid neoplasms and inflammatory simulators. The term CD30+ pseudolymphoma is proposed to designate inflammatory processes with CD30+ T cells. The final diagnosis of CD30+ LPD is based on a synthesis of clinical, histologic, phenotypic, and molecular genetic findings.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Biomarkers, Tumor / metabolism
  • Humans
  • Ki-1 Antigen / metabolism*
  • Lymphoma, T-Cell, Cutaneous / diagnosis
  • Lymphoproliferative Disorders / diagnosis*
  • Lymphoproliferative Disorders / metabolism
  • Skin / pathology*
  • Skin Diseases / diagnosis*
  • Skin Diseases / metabolism


  • Biomarkers, Tumor
  • Ki-1 Antigen