FGFR3 and p53 protein expressions in patients with pTa and pT1 urothelial bladder cancer

Eur J Surg Oncol. 2006 Mar;32(2):231-7. doi: 10.1016/j.ejso.2005.11.018. Epub 2006 Jan 18.

Abstract

Aims: This study is designed to evaluate the expression and prognostic value of FGFR3 protein expression in patients with pTa/pT1 tumours and to determine the significance of the combinations of FGFR3 and p53 protein expressions in bladder pathogenesis.

Materials and methods: A tissue microarray (TMA) of 107 pTa, and 147 pT1 tumours was constructed. The TMA sections were immunostained with FGFR3 and p53 monoclonal antibodies.

Results: There were significant associations between loss of FGFR3 and tumour stage (p<0.001) and grade (p<0.001) and between p53 overexpression and tumour stage and grade (p<0.001 and p<0.001, respectively). There was no association between FGFR3 and p53 proteins (p=0.107). In addition, tumours with FGFR3+/p53- phenotype have slower recurrence rate than other (FGFR3+/p53+, FGFR3-/p53- and FGFR3-/p53+).

Conclusion: 1-FGFR3 expression is significantly associated with two important prognostic factors; stage and grade. 2-FGFR3 protein expression is not an independent predictive factor for pTa/pT1 tumour recurrence and progression. 3-Tumours with FGFR3+/p53- phenotype seem to have a distinctive pathway in bladder tumorigenesis.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Analysis of Variance
  • Antibodies, Monoclonal
  • Carcinoma, Transitional Cell / chemistry*
  • Carcinoma, Transitional Cell / pathology
  • Carcinoma, Transitional Cell / therapy
  • Chemotherapy, Adjuvant
  • Disease Progression
  • Female
  • Follow-Up Studies
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Male
  • Middle Aged
  • Neoplasm Recurrence, Local / chemistry
  • Neoplasm Staging
  • Phenotype
  • Prognosis
  • Receptor, Fibroblast Growth Factor, Type 3 / analysis*
  • Receptor, Fibroblast Growth Factor, Type 3 / immunology
  • Retrospective Studies
  • Tumor Suppressor Protein p53 / analysis*
  • Tumor Suppressor Protein p53 / immunology
  • Urinary Bladder Neoplasms / chemistry*
  • Urinary Bladder Neoplasms / pathology
  • Urinary Bladder Neoplasms / therapy
  • Urologic Surgical Procedures

Substances

  • Antibodies, Monoclonal
  • Tumor Suppressor Protein p53
  • FGFR3 protein, human
  • Receptor, Fibroblast Growth Factor, Type 3