Mutagenesis and the three R's in yeast

DNA Repair (Amst). 2006 Apr 8;5(4):409-21. doi: 10.1016/j.dnarep.2005.11.006. Epub 2006 Jan 10.


Mutagenesis is a prerequisite for evolution and also is an important contributor to human diseases. Most mutations in actively dividing cells originate during DNA replication as errors introduced when copying an undamaged DNA template or during the bypass of DNA lesions. In addition, mutations can be introduced during the repair of DNA double-strand breaks by either homologous recombination or non-homologous end-joining pathways. Finally, although generally considered to be a very high-fidelity process, the excision repair of DNA damage may be an important contributor to mutagenesis in non-dividing cells. In this review, we will discuss the well-known contributions of DNA replication to mutagenesis in Saccharomyces cerevisiae, as well as the less-appreciated contributions of recombination and repair to mutagenesis in this organism.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • DNA Repair / genetics*
  • DNA Replication / genetics*
  • Mutagenesis / genetics*
  • Recombination, Genetic / genetics*
  • Saccharomyces cerevisiae / genetics*