Detection of serum neopterin for early assessment of dengue virus infection

J Infect. 2006 Sep;53(3):152-8. doi: 10.1016/j.jinf.2005.11.008. Epub 2006 Jan 18.


Objective: Neopterin is generated and released in increased amounts by macrophages upon activation by interferon-gamma during Th1-type immune response. The potential usefulness of neopterin in early prognostic information of dengue virus infection was investigated.

Methods: Neopterin concentrations were determined in serum samples from 110 dengue fever (DF) patients. The neopterin levels were compared with those in 50 measles and 40 influenza patients; 155 healthy blood donors served as controls.

Results: In acute sera of DF patients mean neopterin concentration was 48.2 nmol/L, which was higher than that in patients with measles (mean: 36.3 nmol/L) and influenza (18.8 nmol/L) and in healthy controls (6.7 nmol/L; P<0.001). In the patients with confirmed DF, an early neopterin elevation was detected already at the first day after the onset of symptoms and rose to a maximum level of 54.3 nmol/L 4 days after the onset. Higher increase of neopterin level in DF patients was associated with longer duration of fever and thus predicted the clinical course of the disease.

Conclusions: Neopterin concentrations were found significantly higher in DF patients compared with healthy controls and also with other viral infections (P<0.001) and may allow early assessment of the severity of DF.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Antibodies, Viral / blood
  • Child
  • Child, Preschool
  • Dengue / blood*
  • Dengue / diagnosis*
  • Dengue Virus / immunology
  • Female
  • Fever / blood
  • Humans
  • Influenza, Human / blood
  • Male
  • Measles / blood
  • Middle Aged
  • Neopterin / blood*
  • Time Factors


  • Antibodies, Viral
  • Neopterin