Protein sensors for membrane sterols

Cell. 2006 Jan 13;124(1):35-46. doi: 10.1016/j.cell.2005.12.022.


Cholesterol is an essential component of animal cell membranes, and its concentration is tightly controlled by a feedback system that operates at transcriptional and posttranscriptional levels. Here, we discuss recent advances that explain how cells employ an ensemble of membrane-embedded proteins to monitor sterol concentrations and adjust sterol synthesis and uptake.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Membrane / chemistry
  • Cell Membrane / physiology*
  • Feedback, Physiological / physiology*
  • Humans
  • Membrane Proteins / chemistry
  • Membrane Proteins / physiology*
  • Models, Biological
  • Sterols / chemistry
  • Sterols / metabolism*


  • Membrane Proteins
  • Sterols