Review
doi: 10.1016/j.mce.2005.11.031.
Epub 2006 Jan 4.
Multifunctionality of human 17beta-hydroxysteroid dehydrogenases
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- PMID: 16413960
- DOI: 10.1016/j.mce.2005.11.031
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Review
Multifunctionality of human 17beta-hydroxysteroid dehydrogenases
Mol Cell Endocrinol.
.
Abstract
17Beta-hydroxysteroid dehydrogenases (17beta-HSDs) belong to the family of short chain dehydrogenases/reductases (SDRs) and aldoketo-reductases (AKRs). Some of the enzymes were discovered and named due to their enzymatic activity on steroid substrates or according to their sequence homology to other 17beta-HSDs. During characterisation of these enzymes it turned out that their substrate specificity is broader than first expected and key functions of some 17beta-HSDs in vivo are probably not in steroid metabolism but in basic metabolic pathways. The issue of such multifunctionality is the topic of this review.
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