Ropivacaine compared to bupivacaine for post-tonsillectomy pain relief in children: a randomized controlled study

Int J Pediatr Otorhinolaryngol. 2006 Jul;70(7):1169-73. doi: 10.1016/j.ijporl.2005.12.001. Epub 2006 Jan 18.


Objective: To compare the effects of ropivacaine and bupivacaine on post-tonsillectomy pain in children.

Methods: Forty-six children aged 2-12 years, undergoing tonsillectomy were enrolled in the study. Group 1 (n=16) received bupivacaine, group 2 (n=15) received ropivacaine, and a group 3 (control) (n=15) received 9% NaCl (saline) infiltrated around each tonsil. Pain was evaluated using a modified Children's Hospital of Eastern Ontario Pain Scale (mCHEOPS) recorded 15 min and 1, 4, 12, 16, and 24h postoperatively.

Results: No difference was found in the demographic data among the groups. The pain scores were similar between the bupivacaine and ropivacaine groups (p>0.05). The pain scores in both analgesia groups were significantly (p<0.05) lower 1, 4, 12, 16, and 24h postoperatively compared to the control group. Analgesic requirements and the time to first analgesia were also significantly (p<0.05) different between the analgesia and control groups.

Conclusion: Local ropivacaine infiltration is a safe and effective method and equivalent to bupivacaine for post-tonsillectomy pain.

Publication types

  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Amides / administration & dosage*
  • Anesthetics, Local / administration & dosage*
  • Bupivacaine / administration & dosage*
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Male
  • Pain Measurement
  • Pain, Postoperative / drug therapy*
  • Ropivacaine
  • Tonsillectomy*
  • Treatment Outcome


  • Amides
  • Anesthetics, Local
  • Ropivacaine
  • Bupivacaine