Brain natriuretic peptide is a prognostic parameter in chronic lung disease

Am J Respir Crit Care Med. 2006 Apr 1;173(7):744-50. doi: 10.1164/rccm.200510-1545OC. Epub 2006 Jan 13.


Rationale: The detection of pulmonary hypertension in patients with chronic lung disease has prognostic implications. The brain natriuretic peptide (BNP) has been suggested as a noninvasive marker for the presence and severity of pulmonary hypertension.

Objectives: We evaluated circulating BNP levels as a parameter for the presence and severity of pulmonary hypertension in patients with chronic lung disease.

Methods: BNP levels were measured in 176 consecutive patients with various pulmonary diseases. Right heart catheterization, lung functional testing, and a 6-min walk test were performed. The mean follow-up time was nearly 1 yr.

Measurements and main results: Significant pulmonary hypertension (mean pulmonary artery pressure > 35 mm Hg) was diagnosed in more than one-fourth of patients and led to decreased exercise tolerance and life expectancy. Elevated BNP concentrations identified significant pulmonary hypertension with a sensitivity of 0.85 and specificity of 0.88 and predicted mortality. Moreover, BNP served as a risk factor of death independent of lung functional impairment or hypoxemia in uni- and multivariate analysis.

Conclusion: We suggest BNP as a prognostic marker and as screening parameter for significant pulmonary hypertension in chronic lung disease.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Biomarkers / blood
  • Cardiac Catheterization
  • Cardiac Output / physiology
  • Disease Progression
  • Exercise Test
  • Female
  • Follow-Up Studies
  • Humans
  • Hypertension, Pulmonary / blood
  • Hypertension, Pulmonary / etiology
  • Hypertension, Pulmonary / physiopathology
  • Male
  • Middle Aged
  • Natriuretic Peptide, Brain / blood*
  • Plethysmography
  • Prognosis
  • Prospective Studies
  • Pulmonary Disease, Chronic Obstructive / blood*
  • Pulmonary Disease, Chronic Obstructive / complications
  • Pulmonary Disease, Chronic Obstructive / physiopathology
  • Pulmonary Wedge Pressure / physiology
  • Severity of Illness Index
  • Spirometry
  • Survival Rate / trends


  • Biomarkers
  • Natriuretic Peptide, Brain