Bidirectional behavioral plasticity of memory reconsolidation depends on amygdalar protein kinase A

Nat Neurosci. 2006 Feb;9(2):167-9. doi: 10.1038/nn1628. Epub 2006 Jan 15.


Reconsolidation-the stabilization of a memory after retrieval-is hypothesized to be a critical and distinct component of memory processing, the disruption of which results in memory impairment. In the rat, we found that activation of amygdalar protein kinase A (PKA) was sufficient to enhance memory only when it was retrieved; in contrast, PKA inhibition impaired reconsolidation. This study demonstrates both a selective enhancement and an impairment of memory reconsolidation dependent on amygdalar PKA.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acoustic Stimulation
  • Amygdala / physiology*
  • Animals
  • Behavior, Animal / physiology*
  • Cyclic AMP-Dependent Protein Kinases / metabolism*
  • Fear / physiology
  • Memory / physiology*
  • Neuronal Plasticity / physiology*
  • Rats


  • Cyclic AMP-Dependent Protein Kinases