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. 2006 Feb;38(2):234-9.
doi: 10.1038/ng1693. Epub 2006 Jan 15.

Physiogenomic Resources for Rat Models of Heart, Lung and Blood Disorders

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Physiogenomic Resources for Rat Models of Heart, Lung and Blood Disorders

Renae L Malek et al. Nat Genet. .

Abstract

Cardiovascular disorders are influenced by genetic and environmental factors. The TIGR rodent expression web-based resource (TREX) contains over 2,200 microarray hybridizations, involving over 800 animals from 18 different rat strains. These strains comprise genetically diverse parental animals and a panel of chromosomal substitution strains derived by introgressing individual chromosomes from normotensive Brown Norway (BN/NHsdMcwi) rats into the background of Dahl salt sensitive (SS/JrHsdMcwi) rats. The profiles document gene-expression changes in both genders, four tissues (heart, lung, liver, kidney) and two environmental conditions (normoxia, hypoxia). This translates into almost 400 high-quality direct comparisons (not including replicates) and over 100,000 pairwise comparisons. As each individual chromosomal substitution strain represents on average less than a 5% change from the parental genome, consomic strains provide a useful mechanism to dissect complex traits and identify causative genes. We performed a variety of data-mining manipulations on the profiles and used complementary physiological data from the PhysGen resource to demonstrate how TREX can be used by the cardiovascular community for hypothesis generation.

Comment in

  • Expressing physiology.
    Hubner N. Hubner N. Nat Genet. 2006 Feb;38(2):140-1. doi: 10.1038/ng0206-140. Nat Genet. 2006. PMID: 16444251 No abstract available.

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