A Possible Role of GLP-1 in the Pathophysiology of Early Dumping Syndrome

Dig Dis Sci. 2005 Dec;50(12):2263-7. doi: 10.1007/s10620-005-3046-2.

Abstract

Exaggerated plasma concentrations of GLP-1 precede reactive hypoglycemia after oral glucose in gastrectomy patients, resulting in late dumping syndrome. Recently, we showed that GLP-1 elicits the activation of sympathetic outflow. Because sympathetic activation is thought to be a cause of early dumping, we hypothesized that exaggerated GLP-1 may contribute to the pathophysiology of early dumping syndrome. In 11 patients after gastrectomy and 14 controls, blood pressure, heart rate, and plasma concentrations of norepinephrine, epinephrine, GLP-1, glucagon, insulin, and glucose were measured after oral glucose. In gastrectomy patients, GLP-1, norepinephrine, and heart rate peaked 15 to 30 min after oral glucose. Significant positive correlations were found among GLP-1, norepinephrine, and heart rate at 30 min, and these parameters at 30 min were significantly higher in patients with early dumping syndrome. These results suggest that GLP-1 is involved in the pathophysiology of early dumping syndrome.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Analysis of Variance
  • Biomarkers / blood
  • Blood Glucose / analysis
  • Case-Control Studies
  • Catecholamines / blood
  • Dumping Syndrome / blood
  • Dumping Syndrome / diagnosis*
  • Dumping Syndrome / etiology
  • Female
  • Gastrectomy / adverse effects*
  • Gastrectomy / methods
  • Glucagon-Like Peptide 1 / blood*
  • Hemodynamics / physiology*
  • Humans
  • Insulin / blood
  • Linear Models
  • Male
  • Middle Aged
  • Prognosis
  • Reference Values
  • Risk Assessment
  • Sensitivity and Specificity
  • Severity of Illness Index
  • Stomach Neoplasms / pathology
  • Stomach Neoplasms / surgery

Substances

  • Biomarkers
  • Blood Glucose
  • Catecholamines
  • Insulin
  • Glucagon-Like Peptide 1