TP53 gene mutations are rare in nondysplastic Barrett's esophagus

Dig Dis Sci. 2006 Jan;51(1):110-3. doi: 10.1007/s10620-006-3093-3.


In search of potential prognostic markers, we analyzed a large series of tissues of Barrett's esophagus and samples of adenocarcinomas arising in the terrain of Barrett's esophagus for TP53 gene mutations by direct sequencing of exons 5 to 9 of the TP53 gene. While 9 of 21 adenocarcinomas tested (42.9%) contained a TP53 mutation, none of 24 samples from Barrett's esophagus were mutated. This observation suggests that TP53 gene mutation may be a relatively late event in the progression from nondysplastic Barrett's esophagus to adenocarcinoma of esophagus. Therefore, TP53 gene mutations alone are not likely to represent a widely useful prognostic marker of the risk of progression to malignancy, at least not in Barrett's esophagus without dysplasia.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenocarcinoma / genetics
  • Adenocarcinoma / pathology
  • Adult
  • Aged
  • Aged, 80 and over
  • Barrett Esophagus / genetics*
  • Barrett Esophagus / pathology
  • Biopsy
  • DNA / genetics*
  • Disease Progression
  • Esophageal Neoplasms / genetics
  • Esophageal Neoplasms / pathology
  • Exons
  • Female
  • Genes, p53 / genetics*
  • Genetic Markers
  • Humans
  • Male
  • Middle Aged
  • Mutation*
  • Polymerase Chain Reaction
  • Precancerous Conditions / genetics
  • Precancerous Conditions / pathology
  • Retrospective Studies
  • Risk Factors


  • Genetic Markers
  • DNA