Multi-slice DCE-MRI data using P760 distinguishes between metastatic and non-metastatic rodent prostate tumors

MAGMA. 2006 Feb;19(1):15-21. doi: 10.1007/s10334-005-0022-y. Epub 2006 Jan 17.


An intermediate molecular weight contrast agent P760 was used to investigate the ability of multi-slice dynamic contrast-enhanced MRI (DCE-MRI) to distinguish metastatic from non-metastatic rodent prostate tumors. Non-metastatic AT2.1 and metastatic AT3.1 prostate tumors originally derived from the Dunning prostate cancer model were implanted on the hind leg of Copenhagen rats. Multi-sliced DCE-MRI data were acquired on a SIGNA 1.5 T scanner and analyzed using a recently developed empirical mathematical model. The P760 multi-slice DCE-MRI data in combination with the empirical mathematical model successfully distinguished between metastatic and non-metastatic rodent prostate tumors. Specifically, fitting the data with the empirical model showed that metastatic tumors had significantly faster contrast media uptake (p<0.001) and slower washout rates (p<0.01) than non-metastatic tumors.

Publication types

  • Evaluation Study
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms*
  • Anatomy, Cross-Sectional / methods*
  • Animals
  • Image Enhancement / methods*
  • Image Interpretation, Computer-Assisted / methods*
  • Imaging, Three-Dimensional / methods*
  • Magnetic Resonance Imaging / methods*
  • Male
  • Organometallic Compounds*
  • Prostatic Neoplasms / classification
  • Prostatic Neoplasms / diagnosis*
  • Prostatic Neoplasms / secondary*
  • Rats
  • Reproducibility of Results
  • Sensitivity and Specificity


  • Organometallic Compounds
  • gadolinium compound P760