Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 73 (1), 72-8

Medications for Migraine Prophylaxis

Affiliations
  • PMID: 16417067
Review

Medications for Migraine Prophylaxis

Seema Modi et al. Am Fam Physician.

Erratum in

  • Am Fam Physician. 2006 Nov 15;74(10):1685

Abstract

Sufficient evidence and consensus exist to recommend propranolol, timolol, amitriptyline, divalproex, sodium valproate, and topiramate as first-line agents for migraine prevention. There is fair evidence of effectiveness with gabapentin and naproxen sodium. Botulinum toxin also has demonstrated fair effectiveness, but further studies are needed to define its role in migraine prevention. Limited evidence is available to support the use of candesartan, lisinopril, atenolol, metoprolol, nadolol, fluoxetine, magnesium, vitamin B2 (riboflavin), coenzyme Q10, and hormone therapy in migraine prevention. Data and expert opinion are mixed regarding some agents, such as verapamil and feverfew; these can be considered in migraine prevention when other medications cannot be used. Evidence supports the use of timed-release dihydroergotamine mesylate, but patients should be monitored closely for adverse effects.

Similar articles

See all similar articles

Cited by 14 articles

See all "Cited by" articles

MeSH terms

Substances

LinkOut - more resources

Feedback