Nanotechnologies for biomolecular detection and medical diagnostics

Curr Opin Chem Biol. 2006 Feb;10(1):11-9. doi: 10.1016/j.cbpa.2006.01.006. Epub 2006 Jan 18.


Nanotechnology-based platforms for the high-throughput, multiplexed detection of proteins and nucleic acids in heretofore unattainable abundance ranges promise to bring substantial advances in molecular medicine. The emerging approaches reviewed in this article, with reference to their diagnostic potential, include nanotextured surfaces for proteomics, a two-particle sandwich assay for the biological amplification of low-concentration biomolecular signals, and silicon-based nanostructures for the transduction of molecular binding into electrical and mechanical signals, respectively.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Biopolymers / chemistry*
  • Diagnostic Techniques and Procedures / instrumentation*
  • Humans
  • Nanostructures / chemistry
  • Nanotechnology / instrumentation
  • Nanotechnology / methods*
  • Protein Array Analysis / instrumentation
  • Protein Array Analysis / methods
  • Sensitivity and Specificity
  • Silicon / chemistry
  • Surface Properties


  • Biopolymers
  • Silicon