CD45: all is not yet crystal clear

Immunology. 2006 Feb;117(2):145-55. doi: 10.1111/j.1365-2567.2005.02265.x.


CD45 has been recognized as an important player in regulating signalling in lymphocytes. However, compared with tyrosine kinases, phosphatases are still poorly understood in terms of the details of their specificity and regulation. Here, the recent progress in understanding the biology of the first recognized receptor tyrosine phosphatase, CD45, is reviewed.

Publication types

  • Review

MeSH terms

  • Evolution, Molecular
  • Genetic Predisposition to Disease
  • Humans
  • Isoenzymes / physiology
  • Leukocyte Common Antigens / genetics
  • Leukocyte Common Antigens / physiology*
  • Polymorphism, Genetic
  • Protein Conformation
  • Signal Transduction / physiology


  • Isoenzymes
  • Leukocyte Common Antigens