Geographical distribution of optic nerve hypoplasia and septo-optic dysplasia in Northwest England

J Pediatr. 2006 Jan;148(1):85-8. doi: 10.1016/j.jpeds.2005.07.031.


Objective: To study the distribution of septo-optic dysplasia (SOD) and optic nerve hypoplasia (ONH) in the Greater Manchester and Lancashire (GM&L) region of Northwest England, and to analyze occurrence by location and over time.

Study design: A population-based incidence study was undertaken for cases of SOD/ONH from GM&L. Standardized incidence ratio (SIR) for each district, relationships between SIRs and possible geographically varying risk factors, and spatial and space-time clustering were analyzed.

Results: Eighty-seven cases had a confirmed diagnosis of ONH/SOD giving an incidence of 10.9/100,000 per year in GM&L. SIRs ranged widely but were significantly elevated (lower confidence limit >100) in three districts: 167%, 192%, and 198%, respectively. All three were high population density, inner-city locations. SIRs were significantly correlated with higher rates of unemployment (r = 0.49, P = .01), dependent children in non-earning households (r = 0.47, P = .02), underage conceptions (r = 0.46, P = .02), and underage pregnancies (r = 0.44, P = .03). There was no evidence of spatial or space-time clustering.

Conclusions: The incidence of ONH/SOD in GM&L was higher than that reported elsewhere. Cases were more common in areas that had higher unemployment and teenage pregnancy rates.

MeSH terms

  • Age Factors
  • Child
  • Child, Preschool
  • England / epidemiology
  • Female
  • Humans
  • Incidence
  • Infant
  • Male
  • Optic Nerve Diseases / epidemiology*
  • Septo-Optic Dysplasia / epidemiology*
  • Socioeconomic Factors