Investigation of fundo-antral reflex in human beings

World J Gastroenterol. 2005 Nov 14;11(42):6676-80. doi: 10.3748/wjg.v11.i42.6676.


Aim: To examine the sensory and motor response(s) of the stomach following fundic distention and to assess whether cholinergic mechanisms influence these responses.

Methods: Fundic tone, gastric sensory responses and antral motility were evaluated in eight healthy volunteers after a probe with two sensors was placed in the antrum and a highly compliant balloon in the fundus. Isobaric balloon distentions were performed with a barostat. Study was repeated in six volunteers after intravenous atropine was given.

Results: Fundic distention induced large amplitude antral contractions in all subjects. The area under the curve was higher (P<0.05) during fundic distention. First sensation was reported at 12+/-4 mmHg, moderate sensation at 18+/-4 mmHg and discomfort at 21+/-4 mmHg. Discomfort was associated with a decrease in antral motility. After atropine was given, the area under the curve of pressure waves and fundic tone decreased (P<0.05). Sensory thresholds were not affected.

Conclusions: Fundic balloon distention induces an antral motor response, the fundo-antral reflex, which in part may be mediated by cholinergic mechanisms.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Animals
  • Atropine / pharmacology
  • Gastric Dilatation
  • Gastric Emptying / physiology
  • Humans
  • Manometry
  • Muscarinic Antagonists / pharmacology
  • Muscle Tonus / drug effects
  • Muscle Tonus / physiology
  • Pressure
  • Pyloric Antrum / drug effects
  • Pyloric Antrum / physiology*
  • Reflex*
  • Sensation / physiology
  • Stomach / drug effects
  • Stomach / physiology*


  • Muscarinic Antagonists
  • Atropine