Promoter polymorphism rs3087456 in the MHC class II transactivator gene is not associated with susceptibility for selected autoimmune diseases in German patient groups

Int J Immunogenet. 2006 Feb;33(1):59-61. doi: 10.1111/j.1744-313X.2006.00568.x.


We analysed whether the single nucleotide polymorphism (SNP) rs3087456 in the promoter of the MHC class II transactivator (MHC2TA) gene is associated with manifestation of rheumatoid arthritis, multiple sclerosis, narcolepsy and Wegener granulomatosis. The recently reported association in a northern population of the MHC2TA variation with these autoimmune diseases is not evident in the German population.

MeSH terms

  • Arthritis, Juvenile / genetics
  • Arthritis, Rheumatoid / genetics
  • Autoimmune Diseases / genetics*
  • Cohort Studies
  • Gene Frequency
  • Genetic Predisposition to Disease*
  • Germany
  • Granulomatosis with Polyangiitis / genetics
  • Humans
  • Multiple Sclerosis / genetics
  • Narcolepsy / genetics
  • Nuclear Proteins / genetics*
  • Polymorphism, Genetic
  • Polymorphism, Single Nucleotide
  • Promoter Regions, Genetic
  • Trans-Activators / genetics*


  • MHC class II transactivator protein
  • Nuclear Proteins
  • Trans-Activators