Anti-interleukin-6 autoantibodies in rheumatic diseases. Increased frequency in the sera of patients with systemic sclerosis

Arthritis Rheum. 1992 Aug;35(8):940-3. doi: 10.1002/art.1780350814.


Objective: To investigate the presence and the roles of anti-interleukin-6 (anti-IL-6) autoantibodies in rheumatic diseases, and to further elucidate clinical and pathophysiologic significance of anticytokine autoantibodies.

Methods: Anti-IL-6 IgG autoantibodies were measured by the 125I-IL-6 binding activity of IgG, which was isolated from serum by protein A-Sepharose.

Results: Nine of 52 sera (17.3%) from patients with systemic sclerosis (SSc) contained anti-IL-6 antibodies, whereas only 1.9% of sera from normal subjects and 0-5% of sera from patients with other rheumatic diseases were positive for the antibodies. Moreover, anti-IL-6 autoantibodies were found predominantly among patients with the limited form of SSc (42.9%), compared with those with the diffuse form (7.9%).

Conclusion: Anti-IL-6 IgG autoantibodies were detected in patients with SSc, particularly those with the limited form of the disease, at a significantly increased frequency compared with normal subjects and patients with other rheumatic diseases. These results suggest that the development of anti-IL-6 autoantibodies and IL-6 may have a role in the pathophysiology of SSc.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Autoantibodies / analysis*
  • Autoantibodies / immunology
  • Autoantibodies / physiology
  • Female
  • Humans
  • Interleukin-6 / immunology*
  • Iodine Radioisotopes
  • Male
  • Middle Aged
  • Rheumatic Diseases / blood
  • Rheumatic Diseases / immunology*
  • Rheumatic Diseases / physiopathology
  • Scleroderma, Systemic / blood
  • Scleroderma, Systemic / immunology*
  • Scleroderma, Systemic / physiopathology


  • Autoantibodies
  • Interleukin-6
  • Iodine Radioisotopes