Effect of micronutrient supplementation on health and nutritional status of schoolchildren: growth and morbidity

Nutrition. 2006 Jan;22(1 Suppl):S8-14. doi: 10.1016/j.nut.2005.07.011.


Objective: We evaluated the effect of a micronutrient-fortified beverage on growth and morbidity in apparently healthy schoolchildren.

Methods: This was a double-blind, placebo-controlled, matched-pair, cluster, randomized study in semi-urban middle-income residential schoolchildren aged 6 to 16 y. Anthropometrics (height and weight), clinical symptoms of deficiency, and morbidity data were collected at baseline in the supplemented group (n = 446 in 10 grades) and the placebo group (n = 423 in 10 grades) and after 14 mo of supplementation (n = 355 in the supplement group and n = 340 in the placebo group from nine pairs).

Results: After 14 mo of supplementation, there was a significant increase in mean increments of height and weight z scores of -0.04 and 0.02, respectively, in the supplemented group compared with -0.14 and -0.09 in the placebo group. Velocity of weight (3.56 versus 3.00) was significantly (P < 0.01) higher with supplementation. Although there were no differences in the incidence of common childhood diseases such as fever, cough and cold, diarrhea, and ear infections elicited for a reference period of 1 mo at every quarterly follow-up examination, the mean duration of illness (calculated per person per year) was significantly shorter (5.0 d) in the supplemented group than in the placebo group (7.4 d).

Conclusions: The micronutrient-fortified beverage was beneficial in promoting growth and decreasing duration of common illnesses among middle-class residential schoolchildren who had adequate energy and protein intakes.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Anthropometry
  • Body Height / drug effects*
  • Body Weight / drug effects*
  • Child
  • Cluster Analysis
  • Double-Blind Method
  • Female
  • Food, Fortified*
  • Health Status
  • Humans
  • India
  • Male
  • Micronutrients* / administration & dosage
  • Micronutrients* / deficiency
  • Micronutrients* / pharmacology
  • Morbidity*
  • Nutritional Status / drug effects
  • Schools
  • Severity of Illness Index
  • Treatment Outcome


  • Micronutrients