Histamine: an early messenger in inflammatory and immune reactions

Immunol Today. 1992 May;13(5):154-6. doi: 10.1016/0167-5699(92)90117-p.


The local concentration of histamine at sites of inflammation and immune responses is invariably high. Recent studies suggest that the biological relevance of this accumulation of histamine extends beyond its well-characterized role in mediating allergic reactions. In this article, András Falus and Katherine Merétey describe a possible function for histamine in cytokine-governed regulation of inflammatory and immune cascades.

Publication types

  • Review

MeSH terms

  • Acute-Phase Reaction
  • Animals
  • Cytokines / biosynthesis
  • Cytokines / physiology*
  • Histamine / physiology*
  • Humans
  • Immunity, Cellular*
  • Inflammation / metabolism*
  • Mice
  • Models, Biological
  • Receptors, Histamine / classification
  • Receptors, Histamine / drug effects
  • Receptors, Histamine / physiology*
  • Signal Transduction


  • Cytokines
  • Receptors, Histamine
  • Histamine