Effect of vitamin C supplementations on iron deficiency anemia in Chinese children

Biomed Environ Sci. 1992 Jun;5(2):125-9.


A total of 65 children with mild iron deficiency anemia (IDA) were divided into 5 groups, and received 0, 25, 50, 100 and 150 mg/day of vitamin C (VC) respectively every day for 8 weeks. Hemoglobin, serum ferritin, free erythrocyte and hematocrit were determined every week. At a daily average intake of about 30 mg of VC and 7.5 mg of Fe, the results of the study indicate that: (1) VC supplement alone could effectively control children's IDA, and a dose-dependent relationship was observed. (2) 50 mg/day of VC is the most efficient dosage and 6 weeks is the shortest time for an effective therapy. (3) With a diet predominantly comprised of plant foods, it is suggested that appropriate dose of VC should be supplemented for the children during winter and spring in northeastern areas of China.

MeSH terms

  • Anemia, Hypochromic / blood
  • Anemia, Hypochromic / drug therapy*
  • Ascorbic Acid / administration & dosage*
  • Child, Preschool
  • China
  • Dose-Response Relationship, Drug
  • Female
  • Ferritins / blood
  • Hematocrit
  • Hemoglobins / analysis
  • Humans
  • Male
  • Protoporphyrins / blood
  • Time Factors


  • Hemoglobins
  • Protoporphyrins
  • Ferritins
  • Ascorbic Acid