ILSMRs (intensifier of beta-lactam-susceptibility in methicillin-resistant Staphylococcus aureus) from Tara [Caesalpinia spinosa (Molina) Kuntze]

K Kondo; Y Takaishi; H Shibata; T Higuti

doi:10.1016/j.phymed.2004.08.001

ILSMRs (intensifier of beta-lactam-susceptibility in methicillin-resistant Staphylococcus aureus) from Tara [Caesalpinia spinosa (Molina) Kuntze]

Phytomedicine. 2006 Feb;13(3):209-12. doi: 10.1016/j.phymed.2004.08.001. Epub 2005 Jul 7.

Authors

K Kondo¹, Y Takaishi, H Shibata, T Higuti

Affiliation

¹ Faculty of Pharmaceutical Sciences, University of Tokushima, Japan.

PMID: 16428032
DOI: 10.1016/j.phymed.2004.08.001

Abstract

Four quinic acid gallates were isolated from the dried pods of Tara [Caesalpinia spinosa (Molina) Kuntze]. These compounds intensified the susceptibility of methicillin-resistant Staphylococcus aureus (MRSA) to oxacillin. 3,4,5-Tri-O-galloylquinic acid methyl ester (2) was the most effective compound of them.

Publication types

Comparative Study

MeSH terms

Anti-Bacterial Agents / pharmacology*
Anti-Bacterial Agents / therapeutic use
Caesalpinia / chemistry*
Drug Synergism
Gallic Acid / analogs & derivatives
Gallic Acid / chemistry
Gallic Acid / pharmacology
Methicillin Resistance
Microbial Sensitivity Tests / methods
Oxacillin / pharmacology
Plant Extracts / chemistry
Plant Extracts / pharmacology
Quinic Acid / analogs & derivatives
Quinic Acid / chemistry
Quinic Acid / pharmacology
Staphylococcal Infections / drug therapy*
Staphylococcus aureus / drug effects*
beta-Lactams / pharmacology*
beta-Lactams / therapeutic use

Substances

Anti-Bacterial Agents
Plant Extracts
beta-Lactams
Quinic Acid
Gallic Acid
Oxacillin