Abstract
In Salmonella enterica, the isc operon contains genes necessary for the synthesis of Fe-S clusters and strains lacking this operon have severe defects in a variety of cellular processes. Other cellular loci that impact Fe-S cluster synthesis to a lesser extent have been described. The cyaY locus encodes a frataxin homolog, and it is shown here that lesions in this locus affect Fe-S cluster metabolism. When present in combination with other lesions, mutations in cyaY can result in a strain with more severe defects than those lacking the isc locus.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Bacterial Proteins / chemistry
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Bacterial Proteins / metabolism*
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Escherichia coli Proteins
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Frataxin
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Iron-Binding Proteins / chemistry*
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Iron-Binding Proteins / genetics
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Iron-Binding Proteins / metabolism
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Iron-Sulfur Proteins / genetics
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Iron-Sulfur Proteins / metabolism*
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Salmonella enterica / genetics
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Salmonella enterica / growth & development
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Salmonella enterica / metabolism*
Substances
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Bacterial Proteins
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CyaY protein, E coli
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Escherichia coli Proteins
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Iron-Binding Proteins
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Iron-Sulfur Proteins