Malignant hyperthermia following systemic rewarming after hypothermic cardiopulmonary bypass

Anesth Analg. 2006 Feb;102(2):372-5. doi: 10.1213/01.ane.0000189596.70694.36.


Malignant hyperthermia (MH) is a rare hypermetabolic disorder of skeletal muscle that can be fatal if not recognized and treated aggressively. We describe a patient with a suspected family history of MH who developed hyperpyrexia, acidosis, and hypermetabolism after cardiac surgery despite a nontriggering anesthetic. No drugs were identified as being causative and we theorize that systemic rewarming was the inciting cause of MH in this MH-susceptible individual via a mechanism similar to heat stroke.

Publication types

  • Case Reports

MeSH terms

  • Cardiopulmonary Bypass*
  • Coronary Artery Bypass
  • Humans
  • Hypothermia, Induced*
  • Male
  • Malignant Hyperthermia / diagnosis*
  • Malignant Hyperthermia / etiology
  • Middle Aged
  • Postoperative Complications*
  • Rewarming / adverse effects*