The molecular basis for calcium-dependent axon pathfinding

Nat Rev Neurosci. 2006 Feb;7(2):115-25. doi: 10.1038/nrn1844.


Ca(2+) signals have profound and varied effects on growth cone motility and guidance. Modulation of Ca(2+) influx and release from stores by guidance cues shapes Ca(2+) signals, which determine the activation of downstream targets. Although the precise molecular mechanisms that underlie distinct Ca(2+)-mediated effects on growth cone behaviours remain unclear, recent studies have identified important players in both the regulation and targets of Ca(2+) signals in growth cones.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Axons / physiology*
  • Calcium / metabolism*
  • Calcium Signaling / genetics*
  • Growth Cones / physiology
  • Humans
  • Models, Neurological
  • Neurons / cytology*


  • Calcium