A novel strategy for protection against organophosphate toxicity: Evolution of cyclic inhibitors with high affinity for the acetylcholinesterase peripheral site

Chem Biol Interact. 2005 Dec 15:157-158:370. doi: 10.1016/j.cbi.2005.10.056.
No abstract available

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Acetylcholinesterase / chemistry*
  • Acetylcholinesterase / metabolism*
  • Cholinesterase Inhibitors / chemistry
  • Cholinesterase Inhibitors / toxicity*
  • Drug Design
  • Organophosphorus Compounds / antagonists & inhibitors*
  • Organophosphorus Compounds / chemistry
  • Organophosphorus Compounds / toxicity*
  • Peptides, Cyclic / chemistry
  • Peptides, Cyclic / pharmacology*

Substances

  • Cholinesterase Inhibitors
  • Organophosphorus Compounds
  • Peptides, Cyclic
  • Acetylcholinesterase