Ethyl mercury poisoning during a protein A immunoadsorption treatment

Am J Kidney Dis. 2006 Feb;47(2):e31-4. doi: 10.1053/j.ajkd.2005.10.026.

Abstract

We describe the case of a 38-year-old woman with Guillain-Barré syndrome who was accidentally intoxicated with thimerosal, a column disinfectant containing ethyl mercury, during a protein A immunoadsorption treatment. The 1-time overdose caused by an equipment handling error led to a maximum blood serum mercury level of 2,250 microg/L, thus exceeding the normal blood reference range by a factor of approximately 200. Although the patient did not show short-or long-term clinical signs of mercury intoxication, she was treated with chelation therapy, and we replaced thimerosal with a commercially available mercury-free disinfectant, suggesting that thimerosal is no longer indicated for preservation of protein A columns.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Disinfectants / poisoning*
  • Ethylmercury Compounds / poisoning*
  • Female
  • Humans
  • Immunosorbent Techniques*
  • Staphylococcal Protein A*
  • Thimerosal / poisoning*

Substances

  • Disinfectants
  • Ethylmercury Compounds
  • Staphylococcal Protein A
  • Thimerosal