Fat-specific transgenic expression of resistin in the spontaneously hypertensive rat impairs fatty acid re-esterification

Int J Obes (Lond). 2006 Jul;30(7):1157-9. doi: 10.1038/sj.ijo.0803237. Epub 2006 Jan 24.


Objective: To investigate the mechanism by which fat-specific transgenic expression of resistin affects fatty acid metabolism in the spontaneously hypertensive rat (SHR).

Design: Basal- and adrenaline-stimulated lipolysis, basal- and insulin-stimulated lipogenesis as well as the site (glycerol versus acyl moiety) of glucose incorporated into triglycerides were determined in adipose tissue isolated from SHR-Resistin transgenic and SHR control rats.

Results: A moderate expression of transgenic resistin in adipose tissue was associated with significant increase in the FFA/glycerol ratio during adrenaline-stimulated lipolysis in the SHR-Resistin transgenic rats (3.27+/-0.26) compared to SHR controls (2.11+/-0.10, P=0.0005). Transgenic SHR also exhibited a significant decrease in FFA re-esterification in adipose tissue (approximately by 23%).

Conclusion: These findings raise the possibility that the prodiabetic effects of transgenic resistin may be partly mediated by increased FFA release from adipose tissue due to impaired FFA re-esterification in adipocytes.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adipocytes / metabolism
  • Adipose Tissue / metabolism*
  • Animals
  • Animals, Genetically Modified
  • Epinephrine / pharmacology
  • Esterification
  • Fatty Acids, Nonesterified / metabolism*
  • Glucose / metabolism
  • Glycerol / metabolism
  • Lipolysis / drug effects
  • Lipolysis / physiology
  • Rats
  • Rats, Inbred SHR
  • Resistin / genetics
  • Resistin / metabolism
  • Resistin / physiology*


  • Fatty Acids, Nonesterified
  • Resistin
  • Glucose
  • Glycerol
  • Epinephrine