Gender differences in health-related quality of life of adolescents with cystic fibrosis

Health Qual Life Outcomes. 2006 Jan 24;4:5. doi: 10.1186/1477-7525-4-5.


Background: Female patients with cystic fibrosis (CF) have consistently poorer survival rates than males across all ages. To determine if gender differences exist in health-related quality of life (HRQOL) of adolescent patients with CF, we performed a cross-section analysis of CF patients recruited from 2 medical centers in 2 cities during 1997-2001.

Methods: We used the 87-item child self-report form of the Child Health Questionnaire to measure 12 health domains. Data was also collected on age and forced expiratory volume in 1 second (FEV1). We analyzed data from 98 subjects and performed univariate analyses and linear regression or ordinal logistic regression for multivariable analyses.

Results: The mean (SD) age was 14.6 (2.5) years; 50 (51.0%) were female; and mean FEV1 was 71.6% (25.6%) of predicted. There were no statistically significant gender differences in age or FEV1. In univariate analyses, females reported significantly poorer HRQOL in 5 of the 12 domains. In multivariable analyses controlling for FEV1 and age, we found that female gender was associated with significantly lower global health (p < 0.05), mental health (p < 0.01), and general health perceptions (p < 0.05) scores.

Conclusion: Further research will need to focus on the causes of these differences in HRQOL and on potential interventions to improve HRQOL of adolescent patients with CF.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adolescent
  • Child
  • Cross-Sectional Studies
  • Cystic Fibrosis / physiopathology*
  • Cystic Fibrosis / psychology
  • Female
  • Forced Expiratory Volume
  • Humans
  • Linear Models
  • Male
  • Multivariate Analysis
  • Ohio
  • Quality of Life* / psychology
  • Regression Analysis
  • Sex Factors*
  • Sickness Impact Profile*
  • Surveys and Questionnaires