G-protein-coupled receptors: the new dopamine receptor subtypes

Curr Opin Neurobiol. 1992 Jun;2(3):275-81. doi: 10.1016/0959-4388(92)90115-2.

Abstract

The family of genes encoding G-protein-coupled dopamine receptors continues to grow with the recent cloning of a fifth member. The availability of these clones has revolutionized the dopamine receptor field. Expression of individual dopamine receptors is permitting the detailed analysis of their pharmacology and coupling to second messenger systems, while probes based on the receptors' nucleotide sequences are being used to gain new insights into their tissue distribution and genetics.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • GTP-Binding Proteins / genetics
  • GTP-Binding Proteins / metabolism*
  • Humans
  • Molecular Sequence Data
  • Receptors, Dopamine / genetics
  • Receptors, Dopamine / metabolism*
  • Receptors, Dopamine / physiology
  • Sequence Alignment

Substances

  • Receptors, Dopamine
  • GTP-Binding Proteins