Neuronal Ca2+ signalling takes the local route

Curr Opin Neurobiol. 1992 Jun;2(3):302-7. doi: 10.1016/0959-4388(92)90119-6.


The past year has seen several sets of experimental results demonstrate that fast, large and highly localized rises in intracellular Ca2+ concentration can occur in neurons. These results confirm previous theoretical predictions of acute spatial compartmentalization of Ca2+ signalling, and document a form of signalling that may occur whenever rapid and local signal processing is the goal. The dimensions involved present severe challenges for attempts to directly measure these signalling events.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Calcium / physiology*
  • Humans
  • Neurons / physiology*
  • Signal Transduction / physiology*


  • Calcium