Enigma, a mitochondrial protein affecting lifespan and oxidative stress response in Drosophila

Proc Natl Acad Sci U S A. 2006 Jan 31;103(5):1307-12. doi: 10.1073/pnas.0510564103. Epub 2006 Jan 24.


Deregulation of energy metabolism by external interventions or mutations in metabolic genes can extend lifespan in a wide range of species. We describe mutations in Drosophila melanogaster that confer resistance to oxidative stress and display a longevity phenotype. These phenotypes are associated with molecular lesions in a hitherto uncharacterized gene we named Enigma. We show that Enigma encodes a mitochondrial protein with homology to enzymes of the beta-oxidation of fatty acids and that mutations in this locus affect lipid homeostasis. Our analysis provides further support to the notion that lipid metabolism may play a central role in metazoan lifespan regulation.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adaptor Proteins, Signal Transducing
  • Alleles
  • Animals
  • Cytoskeletal Proteins
  • Drosophila Proteins / metabolism
  • Drosophila Proteins / physiology*
  • Drosophila melanogaster
  • Gene Expression Regulation, Developmental
  • Homozygote
  • Intracellular Signaling Peptides and Proteins / physiology*
  • LIM Domain Proteins
  • Lipids / chemistry
  • Microscopy, Fluorescence
  • Mitochondria / metabolism*
  • Mitochondrial Proteins / metabolism
  • Mitochondrial Proteins / physiology*
  • Models, Genetic
  • Mutation
  • Oligonucleotide Array Sequence Analysis
  • Oxidative Stress*
  • Oxygen / metabolism
  • Paraquat / pharmacology
  • Phenotype
  • RNA Interference
  • Subcellular Fractions
  • Time Factors
  • Triglycerides / metabolism


  • Adaptor Proteins, Signal Transducing
  • Cytoskeletal Proteins
  • Drosophila Proteins
  • Intracellular Signaling Peptides and Proteins
  • LIM Domain Proteins
  • Lipids
  • Mitochondrial Proteins
  • PDLIM7 protein, human
  • Triglycerides
  • egm protein, Drosophila
  • Paraquat
  • Oxygen