Obesity, Breast Cancer and the Role of Adipocytokines

Asian Pac J Cancer Prev. Oct-Dec 2005;6(4):547-52.

Abstract

Obesity is a worldwide problem which impacts the risk and prognosis of some of the more common forms of cancer, including breast cancer in post-menopausal women. As the basis for understanding the potential mechanisms of obesity and cancer relationship has advanced, a number of new hypotheses have emerged. The adipocytokines are a complex group of biologically active polypeptides. Leptin is a growth hormone, secreted by adipose tissue, whose levels are normally elevated in obese individuals and may have a promoting effect on carcinogenesis and metastasis of breast cancer, possibly in an autocrine manner. Leptin interferes with the insulin signaling pathway and in type 2 diabetes plasma leptin levels are found to be correlated with the degree of insulin resistance, a relationship independent of body mass. This relationship might provide a mechanistic explanation for promotion potential.

Publication types

  • Review

MeSH terms

  • Adipocytes / physiology*
  • Breast Neoplasms / etiology*
  • Cytokines / physiology*
  • Female
  • Humans
  • Obesity / complications*
  • Peptide Hormones / physiology

Substances

  • Cytokines
  • Peptide Hormones