Innate immunity and the pneumococcus

Microbiology. 2006 Feb;152(Pt 2):285-293. doi: 10.1099/mic.0.28551-0.


The innate immune system provides a non-specific first line of defence against microbes and is crucial both in the development and effector stages of subsequent adaptive immune responses. Consistent with its importance, study of the innate immune system is a broad and fast-moving field. Here we provide an overview of the recent key advances made in this area with relation to the important pathogen Streptococcus pneumoniae (the pneumococcus).

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Humans
  • Immunity, Innate / physiology*
  • Pneumococcal Infections / immunology*
  • Pneumococcal Infections / microbiology
  • Pneumococcal Infections / mortality
  • Pneumococcal Infections / prevention & control*
  • Pneumococcal Vaccines / administration & dosage*
  • Streptococcus pneumoniae*
  • Toll-Like Receptors / physiology


  • Pneumococcal Vaccines
  • Toll-Like Receptors