Abstract
Piperine, a trans-trans isomer of 1-piperoyl-piperidine, in combination with ciprofloxacin markedly reduced the MICs and mutation prevention concentration of ciprofloxacin for Staphylococcus aureus, including methicillin-resistant S. aureus. The enhanced accumulation and decreased efflux of ethidium bromide in the wild-type and mutant (CIPr-1) strains in the presence of piperine suggest its involvement in the inhibition of bacterial efflux pumps.
MeSH terms
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Alkaloids / pharmacology*
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Anti-Infective Agents / pharmacology*
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Benzodioxoles
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Ciprofloxacin / pharmacology*
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Drug Resistance, Bacterial
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Ethidium / pharmacokinetics
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Microbial Sensitivity Tests
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Piperidines / pharmacology*
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Polyunsaturated Alkamides
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Staphylococcus aureus / drug effects*
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Staphylococcus aureus / metabolism
Substances
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Alkaloids
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Anti-Infective Agents
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Benzodioxoles
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Piperidines
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Polyunsaturated Alkamides
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Ciprofloxacin
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Ethidium
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piperine