Phosphoinositide 3-kinase controls early and late events in mammalian cell division

EMBO J. 2006 Feb 22;25(4):655-61. doi: 10.1038/sj.emboj.7600967. Epub 2006 Jan 26.


Phosphoinositide 3-kinase (PI3K) plays a crucial role in triggering cell division. To initiate this process, PI3K induces two distinct routes, of which one promotes cell growth and the other regulates cyclin-dependent kinases. Fine-tuned PI3K regulation is also required for later cell cycle phases. Here, we review the multiple points at which PI3K controls cell division and discuss its impact on human cancer.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Division / physiology*
  • Cyclin-Dependent Kinases / metabolism*
  • Humans
  • Neoplasms / enzymology*
  • Phosphatidylinositol 3-Kinases / metabolism*
  • Signal Transduction*


  • Phosphatidylinositol 3-Kinases
  • Cyclin-Dependent Kinases