Retinol-binding protein, acute phase reactants and Helicobacter pylori infection in patients with gastric adenocarcinoma

World J Gastroenterol. 2005 Dec 7;11(45):7174-8. doi: 10.3748/wjg.v11.i45.7174.


Aim: To determine the serum levels of c-reactive protein (CRP), transferrin (TRF), a2-macroglobulin (A2M), ceruloplasmin (CER), a1-acid glycoprotein (AAG), pre-albumin (P-ALB) and retinol-binding protein (RBP) in gastric carcinoma patients and to explore their possible correlation with underlying Helicobacter pylori (H pylori) infection.

Methods: We measured the serum levels of CRP, TRF, A2M, CER, AAG, P-ALB, and RBP in 153 preoperative patients (93 males; mean age: 63.1+/-11.3 years) with non-cardia gastric adenocarcinoma and 19 healthy subjects.

Results: The levels of CRP, CER, RBP, and AAG in cancer patients were significantly higher than those in healthy controls (P<0.0001), while no difference was found regarding the TRF, P-ALB, and A2M levels. Cancer patients with H pylori infection had significantly lower RBP values compared to non-infected ones (P<0.0001) and also higher values of CRP and AAG (P = 0.09 and P = 0.08, respectively).

Conclusion: High serum levels of CRP, CER and AAG in cancer patients do not seem to be related to H pylori infection. Retinol-binding protein seems to discriminate between infected and non-infected patients with gastric carcinoma. Further studies are needed to explore if it is directly involved in the pathogenesis of the disease or is merely an epiphenomenon.

MeSH terms

  • Acute-Phase Proteins / metabolism
  • Adenocarcinoma / blood
  • Adenocarcinoma / complications*
  • Adenocarcinoma / microbiology
  • Aged
  • Biomarkers, Tumor / blood
  • Case-Control Studies
  • Female
  • Helicobacter Infections / complications*
  • Helicobacter pylori*
  • Humans
  • Male
  • Middle Aged
  • Retinol-Binding Proteins / metabolism
  • Stomach Neoplasms / blood
  • Stomach Neoplasms / complications*
  • Stomach Neoplasms / microbiology


  • Acute-Phase Proteins
  • Biomarkers, Tumor
  • Retinol-Binding Proteins