Wnt signalling in lung development and diseases

Respir Res. 2006 Jan 26;7(1):15. doi: 10.1186/1465-9921-7-15.


There are several signalling pathways involved in lung organogenesis including Notch, TGFbeta/BMP, Sonic hedgehog (Shh), FGF, EGF, and Wnt. Despite the widely acknowledged significance of Wnt signalling in embryonic lung development, the role of different Wnt pathways in lung pathologies has been slow to emerge. In this review, we will present a synopsis of current Wnt research with particular attention paid to the role of Wnt signals in lung development and in pulmonary diseases.

Publication types

  • Review

MeSH terms

  • Animals
  • Humans
  • Lung / embryology*
  • Lung / metabolism*
  • Lung Diseases / embryology*
  • Lung Diseases / metabolism*
  • Models, Biological*
  • Signal Transduction*
  • Wnt Proteins / metabolism*


  • Wnt Proteins