A positive association has previously been demonstrated between chronic aerobic exercise and prior maximal exercise and enhanced dorsal foot skin perfusion in physically active individuals with type 2 diabetes. The current study examined whether an 8-week resistance training program would also positively affect cutaneous perfusion in type 2 diabetic individuals. Ten individuals with type 2 diabetes and nine similar nondiabetic controls participated in 8 weeks of moderate-intensity resistance training. Prior to training, dorsal foot cutaneous perfusion was measured noninvasively by continuous laser Doppler assessment at baseline and during localized heating to 44 degrees C. These measurements were repeated exactly 48-72 h following 8 weeks of resistance training performed 3 days per week. Interstitial nitric oxide (NO) levels were measured concurrently in the contralateral foot dorsum. Neither subject group experienced significant increases in dorsal foot perfusion responsiveness during local heating to 44 degrees C following moderate resistance training, nor did the training significantly enhance baseline skin perfusion. Interstitial NO levels were not significantly different under any condition. At baseline, groups differed only on fasting serum glucose and overall glycemic control. In conclusion, the responsiveness of cutaneous perfusion in response to heating to 44 degrees C is not significantly enhanced by 8 weeks of moderate resistance training in diabetic individuals or their matched controls, independent of interstitial NO levels.