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. 2006 Feb;6(2):67-9.
doi: 10.1016/S1473-3099(06)70361-9.

New Insights Into the Antiviral Effects of Chloroquine

Free PMC article

New Insights Into the Antiviral Effects of Chloroquine

Andrea Savarino et al. Lancet Infect Dis. .
Free PMC article


Can chloroquine interact with sugar-modifying enzymes? This computer-assisted simulation of ligand/protein docking by use of the program GOLD indicates that chloroquine (red) fits to the active site of UDP-N-acetylglucosamine 2-epimerase (grey). This evidence suggests that chloroquine could inhibit the enzyme that catalyses the rate-determining step in the sialic acid biosynthetic pathway.

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